Kevin M. Felsenstein: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors

Michael F. Parker, Donna M. Barten, Carl P. Bergstrom, Joanne J. Bronson, Jason A. Corsa, Milind S. Deshpande, Kevin M. Felsenstein, Valerie L. Guss, Steven B. Hansel, Graham Johnson, Daniel J. Keavy,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 201 KB

english, 2007

2

Corrigendum to “Hydroxytriamides as potent γ-secretase inhibitors”: [Bioorg. Med. Chem. Lett. 14 (2004) 1917]

C.V.C. Prasad, Owen B. Wallace, Jeffrey W. Noonan, Charles P. Sloan, Wai Lau, Shikha Vig, Michael F. Parker, David W. Smith, Steven B. Hansel, Craig T. Polson, Donna M. Barten, Kevin M. Felsenstein, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 205 KB

english, 2004

3

Inhibitors of Aβ production: solid-phase synthesis and SAR of α-hydroxycarbonyl derivatives

Owen B. Wallace, David W. Smith, Milind S. Deshpande, Craig Polson, Kevin M. Felsenstein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

4

Processing of the β-amyloid precursor protein carrying the familial, Dutch-type, and a novel recombinant C-terminal mutation

Felsenstein, Kevin M., Lewis-Higgins, Lore

Journal:

Neuroscience Letters

Year:

1993

Language:

english

File:

PDF, 469 KB

english, 1993

5

γ-Secretase inhibitors and modulators

Golde, Todd E., Koo, Edward H., Felsenstein, Kevin M., Osborne, Barbara A., Miele, Lucio

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2013

Language:

english

File:

PDF, 653 KB

english, 2013

6

Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate

Felsenstein, Kevin M., Ingalls, Kim M., Hunihan, Lisa W., Roberts, Susan B.

Journal:

Neuroscience Letters

Year:

1994

Language:

english

File:

PDF, 561 KB

english, 1994

7

Cholesterol metabolites as endogenous gamma-secretase modulators

Felsenstein, Kevin, Jung, Joo-In, Ladd, Thomas, Ran, Yong, Price, Ashleigh, Galasko, Douglas, Koo, Edward, Shapiro, Gideon, Tang, Yufei, Hochhaus, Guenther, Golde, Todd

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 75 KB

english, 2013

8

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

Jung, Joo In, Premraj, Sasha, Cruz, Pedro E., Ladd, Thomas B., Kwak, Yewon, Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E., Ran, Yong, Padmanabhan, Jaya

Journal:

Year:

2014

Language:

english

File:

PDF, 991 KB

english, 2014

9

Hydroxytriamides as potent γ-secretase inhibitors

C.V.C Prasad, Jeffrey W Noonan, Charles P Sloan, Wai Lau, Shikha Vig, Michael F Parker, David W Smith, Steven B Hansel, Craig T Polson, Donna M Barten, Kevin M Felsenstein, Susan B Roberts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 221 KB

english, 2004

10

Putative gamma secretase modulators lower Aβ42 in multiple in vitro and in vivo models

Rogers, Kathryn, Chesworth, Richard, Felsenstein, Kevin, Shapiro, Gideon, Albayya, Faris, Tu, Zhiming, Spaulding, Darcie, Catana, Florentina, Hrdlicka, Lori, Nolan, Scott, Wen, Melody, Yang, Zhiyong,

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 67 KB

english, 2009

11

CAN WE TARGET CORTICOTROPIN RELEASING FACTOR (CRF) FOR THERAPEUTIC BENEFIT IN AD?

Felsenstein, Kevin M., Park, Hyo-Jin, Ran, Yong, Jung, Joo-In, Holmes, Oliver, Smithson, Lisa, Ceballos-Diaz, Carolina, Wolfe, Michael S., Hauger, Richard, Ryabinin, Andrey, Golde, Todd E.

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014

12

Pharmacokinetic and pharmacodynamic analysis of the gamma-secretase modulator (GSM) EVP-0015962

Felsenstein, Kevin M., Spaulding, Darcie, Yang, Zhiyong, Hodgdon, Hilliary, Costa, Don, Nolan, Scott, Wen, Melody, Lee, Winnie, Hrdlicka, Lori, Catana, Florentina, Albayya, Faris, Tu, Zhiming, Patzke,

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

13

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.87 MB

english, 2014

14

The upstream stimulatory factor functionally interacts with the Alzheimer amyloid β-protein precursor gene

Kovacs, Dora M., Wasco, Wilma, Witherby, Johanna, Felsenstein, Kevin M., Brunei, Franck, Roeder, Robert G., Tanzi, Rudolph E.

Journal:

Human Molecular Genetics

Year:

1995

Language:

english

File:

PDF, 5.14 MB

english, 1995

15

Emerging β-Amyloid Therapies for the Treatment of Alzheimer's Disease

Conway, Kelly A., Baxter, Ellen W., Felsenstein, Kevin M., Reitz, Allen B.

Journal:

Frontiers in Medicinal Chemistry - Online

Year:

2004

Language:

english

File:

PDF, 136 KB

english, 2004

16

Amino-caprolactam derivatives as γ-secretase inhibitors

Michael F. Parker, Joanne J. Bronson, Donna M. Barten, Jason A. Corsa, Wengsheng Du, Kevin M. Felsenstein, Valerie L. Guss, Darcy Izzarelli, Alice Loo, Kate E. McElhone, Larry R. Marcin, Ramesh Padman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 220 KB

english, 2007

17

Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase

Carl P. Bergstrom, Charles P. Sloan, Wai-Yu Lau, David W. Smith, Ming Zheng, Steven B. Hansel, Craig T. Polson, Jason A. Corsa, Donna M. Barten, Kevin M. Felsenstein, Susan B. Roberts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 162 KB

english, 2008

18

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

Kovacs, Dora M., Fausett, Hillary J., Page, Keith J., Kim, Tae-Wan, Moir, Robert D., Merriam, David E., Hollister, Richard D., Hallmark, Olivia G., Mancini, Ronald, Felsenstein, Kevin M.

Journal:

Nature Medicine

Year:

1996

File:

PDF, 778 KB

1996

19

Endogenous cholesterol metabolites as potential Alzheimer's therapeutics

Kevin Felsenstein, Joo-In Jung, Thomas Ladd, Ashleigh Price, Brenda Moore, Yufei Tang, Gideon Shapiro, Guenther Hochhaus, Todd Golde

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 92 KB

english, 2012

20

Shifting a complex debate on γ -secretase cleavage and Alzheimer's disease

Golde, Todd E, Ran, Yong, Felsenstein, Kevin M

Journal:

The EMBO Journal

Year:

2012

Language:

english

File:

PDF, 232 KB

english, 2012

21

Corticotropin-releasing hormone alters Aβ42 production via gamma-secretase

Park, Hyo-Jin, Shults, Cody, Shyqyriu, Eva, Vaziri, Sasha, Felsenstein, Kevin, Ceballos-Diaz, Carolina, Ladd, Thomas, Jung, Joo-In, Kim, Seong-Hun, Golde, Todd

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

22

A Comparative Analysis of Brain and Plasma Aβ Levels in Eight Common Non-Transgenic Mouse Strains: Validation of a Specific Immunoassay for Total Rodent Aβ

George J. Yohrling, Bentham Science Publisher, Kevin M. Felsenstein, Bentham Science Publisher, Kelly A. Conway, Bentham Science Publisher, Adriana Zupa-Fernandez, Bentham Science Publisher, Doug E. B

Journal:

Current Alzheimer Research

Year:

2007

Language:

english

File:

PDF, 240 KB

english, 2007

23

2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

C.V.C. Prasad, Shikha Vig, David W. Smith, Qi Gao, Craig T. Polson, Jason A. Corsa, Valerie L. Guss, Alice Loo, Donna M. Barten, Ming Zheng, Kevin M. Felsenstein, Susan B. Roberts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

24

Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897

Jeffery J. Anderson, Greg Holtz, Patricia P. Baskin, Mary Turner, Blake Rowe, Bowei Wang, Maria Z. Kounnas, Bruce T. Lamb, Donna Barten, Kevin Felsenstein, Ian McDonald, Kumar Srinivasan, Ben Munoz, S

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 510 KB

english, 2005

25

Effects of presenilin mutations on γ-secretase cleavage and turnover of the amyloid β-protein precursor C-terminal fragment

Eunju Pack-Chung, Isaac Cheng, Michael S. Wolfe, Andrew S. Yoo, Kevin M. Felsenstein, Rudolph E. Tanzi, Tae-Wan Kim

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 192 KB

english, 2000

26

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases

Liu, Yanxia, Zhang, Wei, Li, Li, Salvador, Lilibeth A., Chen, Tiantian, Chen, Wuyan, Felsenstein, Kevin M., Ladd, Thomas B., Price, Ashleigh R., Golde, Todd E., He, Jianhua, Xu, Yechun, Li, Yingxia, L

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.32 MB

english, 2012

27

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

28

Regenerative medicine in Alzheimer's disease

Felsenstein, Kevin M., Candelario, Kate M., Steindler, Dennis A., Borchelt, David R.

Journal:

Translational Research

Year:

2014

Language:

english

File:

PDF, 319 KB

english, 2014

29

The next generation of ad therapeutics: The future is now

Kevin M. Felsenstein

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

30

Aβ-modulation: The next generation of ad therapeutics

Perry B. Molinoff, Kevin M. Felsenstein, David W. Smith, Donna M. Barten

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

31

Altered cleavage and secretion of a recombinant β–APP bearing the Swedish familial Alzheimer's disease mutation

Felsenstein, Kevin M., Hunihan, Lisa W., Roberts, Susan B.

Journal:

Nature Genetics

Year:

1994

File:

PDF, 641 KB

1994

32

Aβ Modulation: The Next Generation of AD Therapeutics

KEVIN M. FELSENSTEIN

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 184 KB

english, 2000

33

Expression and Analysis of Presenilin 1 in a Human Neuronal System: Localization in Cell Bodies and Dendrites

David G. Cook, Jane C. Sung, Todd E. Golde, Kevin M. Felsenstein, Boguslaw S. Wojczyk, Rudolph E. Tanzi, John Q. Trojanowski, Virginia M.-Y. Lee and Robert W. Doms

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.54 MB

english, 1996

34

Structure and evolution of a family of interspersed repetitive DNA sequences inCaenorhabditis elegans

Kevin M. Felsenstein, Scott W. Emmons

Journal:

Journal of Molecular Evolution

Year:

1987

Language:

english

File:

PDF, 1.44 MB

english, 1987

35

Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease

Todd E Golde,Kevin Felsenstein,Paramita Chakrabarty…

Journal:

Molecular Neurodegeneration

Year:

2013

Language:

english

File:

PDF, 72 KB

english, 2013

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски